7) Which of the following is used to describe locations of a gene at a specific

Question

7) Which of the following is used to describe locations of a gene at a specific place on the chromosome using microscopic analysis of chromosomes?

A)              DNA sequence of a chromosomal region.

B)              Protein expression from a chromosomal region.

C)              Banding pattern of stained chromosomes.

D)             Comparison to markers located within a few thousand bp.

8) Which of these is an example of cytogenetic mapping?

A)             Hybridization studies in Drosophila determined the location of the yellow gene, which influences body color, to be near the tip of the X chromosome.

B)              Karyotype analysis of humans with familial Down syndrome has identified a relatively small region of chromosome 21 containing genes that cause the Down phenotype.

C)              Analysis of the chromosomes of a strain of mice indicates that a mutant gene has been inserted into the short arm of chromosome 15.

D)             All of these.

E)              None of these

9) Of the two groups who worked on the first draft sequence of the human genome      

A)              Francis Collins and the International Consortium skipped the BAC stage.           

B)              Francis Collins led the effort by Celera Genomics.

C)              Craig Venter's group shotgunned multiple copies of entire genomes into small pieces and used a computer program to assemble the overlaps into larger pieces.

D)             All of the above are true.

Explanation / Answer

Hi,

7)The terminology that is used in biomedical research may be new to students or to readers who do not have previous exposure to this arena. To assist readers with some of the language that they may encounter at this site, or in some of the publications they may explore, a glossary has been assembled and is provided here. Additional depth and other terms may be found at the original sources, or from other biomedical vocabulary providers. Such sources include: The Mouse Genome Informatics Glossary, The National Cancer Institute Thesaurus, and The National Human Genome Research Institute

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