5. Spankophilus J. Weaselsnot is a 68-year-old man recently diagnosed with a spe

Question

5. Spankophilus J. Weaselsnot is a 68-year-old man recently diagnosed with a specific kind of lung cancer that results in unregulated release of ADH from the tumor. (This is an example of ectopic hormone secretion; ectopic in, or from, an abnormal place. Obviously, ADH normally comes from the posterior pituitary, so ADH coming from cells in the lungs would be ectopic.) Because the ectopic release is unregulated, levels of the hormone can become quite high. Table 1 reports selected values from a recent visit to his physician Table 1 - Laboratory results for Mr. Weaselsnot. His systemic blood pressure was normal. Plasma Na+ Plasma osmolarity Urine osmolarity 112 mEq/L (normal: 140 mEq/L) 230 mOsm/L normal: 290 mOsm/L) 1125 mOsm/L (a) Explain Mr. Weaselsnot's urine osmolarity. (3 points) (b) Why was Mr. Weaselsnot's plasma Nat concentration so low? (3 points) (c) What was happening to the volume of Mr. Weaselsnot's total body water (ECF and ICF combined)? Explain. (5 points) (d) What would happen to the volume (size) of Mr. Weaselsnot's cells? Explan. (7 points) (e) Interestingly, Mr. Weaselsnot's blood pressure was normal. How could that be? (5 points)

Explanation / Answer

(e) As the name suggests, Vasopressin is also responsible for constriction of blood vessels to regulate the blood pressure. Thus, increased amounts of hormone will regulate the blood pressure even though, there is an increase in the blood volume.

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