Huntington’s Disease is an autosomal dominant disease that causes neurological d

Question

Huntington’s Disease is an autosomal dominant disease that causes neurological degeneration starting in middle age. The disease affects motor centers in the brain, so patients lose control over their movements. A well-known Huntington’s patient was the singer Woodie Guthrie. Consider a man who is heterozygous and a woman who is homozygous for the normal allele. The man is able to father children early in his life, before the onset of symptoms. What are the genotypes and phenotypes of their possible children? What are the corresponding probabilities?

Explanation / Answer

Answer:-

1.man is heterozygous with genotype-Hh.

2.woman is homozygous with normal allele genotype-hh.

3.phenotypes of children:-2 healthy children and 2 children with disease.

4.genotype of children:- Hh,Hh,hh,hh.

5.probabilities:- 50% healthy children(hh) and 50% huntington's disease children(Hh).

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