Translational repression of cad mRNA requires: a) d4EHP b) W114 (Tryptophan 114)

Question

Translational repression of cad mRNA requires:
a) d4EHP b) W114 (Tryptophan 114) c) W85 d) Bicoid e) BBR (Bicoid Binding Region) f) all of the above
My answer would be all of the above, just because I think atleast d4EHP and Bicoid are necessary. I would just like toconfirm.
a) d4EHP b) W114 (Tryptophan 114) c) W85 d) Bicoid e) BBR (Bicoid Binding Region) f) all of the above
My answer would be all of the above, just because I think atleast d4EHP and Bicoid are necessary. I would just like toconfirm.

Explanation / Answer

      Yes, your answer of allthe above option is right but I would like to add few points.       d4EHP is a cap bindingprotein that repressess cad m-RNA translation by interactingsimultaneously with the 5' cap       structure of m-RNA.       I'm not sure of youroption b and option c but bicoid protein that is required forrepressing cad m-RNA has two       tryptophan residuesin it, but I'm not sure of their positions. May be they are atthese positions 114 and 85. Still I go       with this optionalso.       Bicoid protein associateswith 5' cap bound complex of cad and repressess translation. I t isa specific repressor of cad       m-RNA.       BBR (bicoid bindingprotein):- The simultaneous interactions of d4EHP with capstructure and of bicoid with BBR       renders cad m-RNAtranslation inactive.       Hence even I would say theanswer f is the right option that is all the above.

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