A patient has hypertension, osteoporosis, hyperglycemia, immunosuppression, and

Question

A patient has hypertension, osteoporosis, hyperglycemia, immunosuppression, and an unusual accumulation of fat on the trunk and upper back. An MRI shows that one adrenal gland is abnormally large, while the other has atrophied. From the choices shown below, click on the hormonal profile that you would most likely see in your patient. low CRH, low ACTH, high cortisol high CRH, high ACTH, low cortisol low CRH, high ACTH, high cortisol high CRH, high ACTH, high cortisol low CRH, low ACTH, low cortisol high CRH, low ACTH, high cortisol

Explanation / Answer

LOW ACTH, LOW CRH AND HIGH CORTISOL

Relationship between ACTH and CORTISOL:

ACTH Hormone is produced in anterior pituitary gland by CRH stimulating hormone which is produced in the hypothalamus.

ACTH hormone secretion is directly affected or inhibited by Cortisol hormone which is produced in adrenal gland.

Any diseases or disturbance of adrenal gland leads to improper secretion of CORTISOL Hormone.

Adrenal enlargement:

Adrenal gland enlargement leads to high secretion of cortisol hormone, so it turn to lower ACTH and CRH. Cortisol is responsible hormone to control blood sugar, blood pressure, antiinflammation, metabolism.

Increased productivity of cortisol affects its responsible functions turn to cause 1) hypertension 2) high blood sugar 3) osteoporosis 4) abnormal fat deposits.

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