Glomerular Filtration Rate Describe the effect that an increasing blood pressure

Question

Glomerular Filtration Rate Describe the effect that an increasing blood pressure (i.e. MAP) would have on GFR if the kidneys could NOT compensate for this change? Describe the effect increasing blood pressure would have on the volume of urine produced if the kidneys could NOT compensate for this change? In the human body, if MAP is between 80 and 180mmHg, would GFR be expected to change as MAP changes? Explain your answer What would happen to GFR if MAP rises above 180mmHg? Explain your answer, including the exact stimulus and process for producing this change. What would happen to GFR if MAP falls below 80mmHg? Explain your answer, including the exact stimulus and process for producing this change.

Explanation / Answer

1) If the mean arterial pressure (MAP) increases, renal autoregulation causes the afferent arteriole to constrict, preventing the pressure increase from being transmitted to the glomerular capillaries, and keeping the GFR from increasing. Renal autoregulation normally operates to keep GFR steady over a wide range of blood pressures. Note, however, that renal autoregulation is disrupted in chronic kidney disease.

2) Unique mean arterial pressure is 96 mmHg. If the pressure rises above this level, the urine output becomes greater than the intake, and the person will have a negative sodium balance indefinitely until, after sufficient depletion of sodium and of water that goes with the sodium, the pressure falls back to and stabilizes at 96 mm Hg. Conversely, if the arterial pressure falls below 96 mm Hg, then the intake of sodium is greater than the output. This gives a positive sodium balance, with increasing body fluid volumes, this reduced urine output.

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