1. An inhibitory post-synaptic potential changes the membrane potential in which

Question

1. An inhibitory post-synaptic potential changes the membrane potential in which of the following mechanisms? A. Depolarization of the postsynaptic membrane by opening Nat channels B. Depolarization the postsynaptic membrane by opening K+ channels C. Hyperpolarization the postsynaptic membrane by opening Ca2+ channels D. Hyperpolarization of the postsynaptic membrane by opening Cl- channels 2. from ag at bring A. Inhibitory inputs are present on the soma B. EPSPs are arriving very close together in time C. EPSPs are arriving from presynaptic cells that form synapses at a great distance from the axon hillock D. Individual excitatory inputs have a low frequency of activity, enabling the membrane to recover from inactivation between EPSPs 3. Neurons 1 and 2 are stimulated simultaneously. Will neuron 3 fire off and cause the muscle to contract? Neuron 2 Neuron 3 Neuron 1 Synapse Use the following data Neuron Stimulus per knob Resting potentiall Action potential 70m 65 mv 60 mv 60 mv 25 3 +10 mv 65 mv

Explanation / Answer

1) Inhibitory post synaptic potential (IPSP) prevents the development of action potential in the post synaptic membrane. The Inhibitory neurotransmitter (GABA, glycine) are responsible for development of IPSP. It hyperpolarises post synaptic membrane by increasing the permeability to chloride ions by opening ligand gated chloride ion channels thereby decreasing the membrane potential making it more negative. So, the answer for this question is option D.

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