How does organophosphates cause nausea and vomitting? Please, and I mean please

Question

How does organophosphates cause nausea and vomitting? Please, and I mean please be incredibly specific. Just telling me acetylcholine(ACh) is built up due to the fact the organophosphates stop acetylcholinase from breaking down ACh is not good enough.

"AChE breaks ACh into choline and acetic acid. In organophosphate poisoning, organophosphate binds to AChE to prevents its function on ACh. This results in accumulation of ACh in nervous system overstimulation of muscarinic and nicotinic receptors leading to activation of the autonomic and central nervous systems and at nicotinic receptors on skeletal muscle. ACh causes stimulation of vagus nerve. It also causes vasodilatation" - is also not specific enough.

Explanation / Answer

The health effects associated with organophosphate poisoning are a result of excess acetylcholine (ACh) present at different nerves and receptors in the body because acetylcholinesterase is blocked. Accumulation of ACh at motor nerves causes overstimulation of nicotinic expression at the neuromuscular junction. When there is an accumulation of ACh at autonomic ganglia this causes overstimulation of nicotinic expression in the sympathetic system.causes heart rate increase and sweating.

Neurotransmitters such as histamine or Ach are also released to the CTZ, which itself can releases chemicals such as dopamine and serotonin (5HT) that go on to stimulate the vomiting centre, which releases Ach, which then leads to the feelings of nausea and actions of vomiting.

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