1. Folate is required for proper mitosis. Could a folate deficiency affect skin

Question

1. Folate is required for proper mitosis. Could a folate deficiency affect skin and or bone repair? If not, why not? If so, how and why?

2.Vitamin C is required for collagen production. Could a vitamin C deficiency affect skin and / or bone production, maintenance and repair? If not why not? If so, why?

3.Cartilage does not heal as easily as do many other tissues. Why might that be?

4. Why must cartilage die before blood vessles move into a bone that is developing via endochondral ossification?

5.Bone marrow transplants for blood deseases often use blood taken from pelvic bone (ilium) of the donor. What is a benefit of sampling from the ilium rather than the shaft of the femur?

Explanation / Answer

Folate deficiency does affect bone repair.because folate deficiency causes increase plasma homocysteine levels and methylenetetrahydrofolate reductase deteriorate normal collagen crosslink formation.

2.vit c deficiency results in failure of osteoblast to firm the intracellular substance osteoid .without the normal ground substance the deposition of bone is arrested.the resulting scrouting bone is weak.and fractures easily.

3.cortilage doesnot heal easily because it has no blood supply.

4cartilage due before blood vessel move into bone because cartilage has no blood supply abd it does not allow blood vessel to invade.

5.illiac crest has large amount of red bone marrow so it is used and for patient comfort and safety.

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