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for each of the following drugs, state all their targets and immediate effects w

ID: 3478977 • Letter: F

Question

for each of the following drugs, state all their targets and immediate effects within the entire skeletal or smooth muscle contraction/relaxation pathway

D immediate effects within the ENTIRE 11. (25 points) For each of the following drugs, state ALL their targets AN skeletal or smooth muscie contraction/relaxation pathway Ziconotide-inhibits voltage gated calcium channels Sihn Prazosin-alpha adrenergic receptor antagonist 0. t be aple to it won' Ach R antagonist Excess Nicotine Ach nIcotive ach he acn Would be no indcatche and noest Dantroiene- Ryanodine receptor inhibitor KT5926-myosin light chain kinase inhibitor MLC wont be able o he aate wnen it Gets COMe lond to actin So Blebbistatin-inhibits troponin to.s |Oligomycin-inhibitsATP synthesis tio actin tue cross orndge work tl.S Xestopongin C-inhibits (P3 receptor Thapsigargin-inhibits SER prance soe CatSo it wl udnut.rt'tiete uon'ton have' v o relax rioas w neert.to vcwe Cc Cue emorS or over Genistein - blocks potassium leak channels Digitalis- inhibits Na+/K+ ATPase pump um JIt be relaved Wey asthe deplaraton avd Gu tWOMH ee aole to reta isctie reicw

Explanation / Answer

11)

1) Prazosin - alpha adrenergic receptor antagonist. Causes relaxation of vascular smooth muscles resulting in vasodilation thereby decreasing the blood pressure.

2) ziconotide - inhibits voltage gated calcium channels. So, neurotransmitters are not released from the nerve terminal and conduction of action potential is blocked.

3) Bungarotoxin - muscaranic ACh receptor antagonist. It blocks the binding of ACh on its receptor in post synaptic membrane and therefore impulse cannot be transmitted.

4) Excess nicotine - Excess nicotine will cause hyperstimulation of nicotinic acetylcholine receptors in the post synaptic membrane. So, the impulse will be generated and transmitted rapidly causing muscular contraction.

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