The affinity that hemoglobin has for oxygen is affected by many factors, includi
ID: 3478528 • Letter: T
Question
The affinity that hemoglobin has for oxygen is affected by many factors, including the partial pressure of oxygen in the blood (PO2), the partial pressure of carbon dioxide in the blood (Pco2), and temperature. Which of the following best describes what happens to these parameters in the blood as blood flows through highly metabolically active tissue and how hemoglobin’s affinity for oxygen would most likely be affected under these condition?
A. PO2, Pco2, and temperature would all increase, causing hemoglobin’s affinity for oxygen to decrease.
B. PO2 would decrease, and Pco2 and temperature would increase, causing hemoglobin’s affinity for oxygen to increase.
C. PO2 would decrease, and Pco2 and temperature would increase, causing hemoglobin’s affinity for oxygen to decrease.
D. PO2 would increase, and Pco2 and temperature would decrease, causing hemoglobin’s affinity for oxygen to increase.
Explanation / Answer
Blood is flowing through highly metabolically active tissue. It means that the tissue requires more oxygen and releases more carbon dioxide.
Therefore, hemoglobin when reaches near the tissue, it has to release oxygen and binds to carbon dioxide. Binding affinity for oxygen has to decrease and binding affinity for carbon dioxide has to be increased.
pO2 decreases, pCO2 increases, temperature icreases, cause hemoglobin’s affinity for oxygen to decrease.
Option C.
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