truncated protei at the stop codo clinical trials of cystic fibrosis ability to

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truncated protei at the stop codo clinical trials of cystic fibrosis ability to corre 2005. Nature know about t mRNA decay problem for e Start codo 10 consensus g Shine- Dalgarno As are small RNA molecules that bind to / end of mRNA and suppress translation (see Section 14.5). Some eukaryotic mRNAs have internal rsoinding sites downstream of the 5' cap, where ribosomes normally bind. In one investigation, miRNAS did not suppress translation by ribosomes that had attached to internal ribosome-binding sites (R. S. Pillai et al. 2005. Science 309:1573-1576). What does this finding suggest about how miRNAs suppress translation? 57. Give the amino acid sequence of the protein encoded by

Explanation / Answer

mi RNAs are small, non-coding RNA molecules encoded in the genomes of plants , animals, and their viruses. These appear to regulate gene expression post-transcriptionally by binding to 3’-untranslated regions (3’-UTR) of specific mRNAs. These RNAs imperfectly base pair to complementary sequences on target mRNAs to block gene expression.

Somme eukaryotic mRNAs have internal ribosome binding sites. miRNAs would not binf to internal sequences (they bind only to the 3’-UTR). Therefore, internal ribosome binding sites have no complementary sequences to mi RNAs. Hence, ribosomes can bind and continue translation at these sites.

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