EXERCISE F. Analysis and Application 1. What gives skeletal muscle fibers their

Question

EXERCISE F. Analysis and Application 1. What gives skeletal muscle fibers their striations? 2. Describe the role of each thin-filament protein and each thick-filament protein in muscle contraction. 3. Many insecticides contain a compound that is an acetylcholinesterase inhibitor. How would exposure to this poison affect skeletal muscles in a human? G. Clinical Challenge 1. How can children inherit Duchenne's muscular dystrophy (DMD) 2. What is the role of the protein dystrophin in normal muscle function and in DMD?

Explanation / Answer

F1. Striated muscles are formed by sarcomeres. Sarcomeres are repeated arrays of overlapping actin and myosin myofilaments. It shows a regular and distinct arrangement of actin and myosin.

F2. Myosin is the thick filament and actin is the thin filament. On activation by Atp, the head of myosin attaches with actin. The ADP and Pi in myosin are released which pulls the actin and make it to slide. After sliding, the actin is released and Again an ATP is hydrolyzed to activate the pathway.

F3. When the enzyme acetylcholine esterase is inhibited, more acetylcholine (Ach) will be released. This increases the nerve impulse across the muscle junction thereby causing hyperstimulation of muscles. This will end up in muscle spasms. Repeated uncontrollable nerve impulse and muscle spasm may lead to paralysis and sometimes death.

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