PPatients with Laron dwarfism have a loss of function mutation of the growth hor

ID: 3475866 • Letter: P

Question

PPatients with Laron dwarfism have a loss of function mutation of the growth hormone receptor gene. Choose all that are true in these patients.

GHRH secretion will be increased.

Somatostatin secretion will be increased by both lower levels of IGF-1 and higher levels of growth hormone.

Growth hormone secretion will be increased because of lower levels of feedback of IGF-1 directly on the pituitary as well as other influences.

Blood glucose levels will be high because of growth hormone's metabolic effects.

GHRH secretion will be increased.

Somatostatin secretion will be increased by both lower levels of IGF-1 and higher levels of growth hormone.

in Laron dwarfism patient

GHRH secretion will be increased due to negative feedback mechanism

Growth hormone secretion will be increased because of lower levels of feedback of IGF-1 directly on the pituitary as well as other influences.

Somatostatin secretion will be increased by both lower levels of IGF-1 and higher levels of growth hormone.

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