You have identified a constituitively open monovalent cation channel and wish to

Question

You have identified a constituitively open monovalent cation channel and wish to determine its selectiveity properties. A bi-ionic experiemnt is performed under conditions where equal molar concentration of Na+ and K+ are placed in the extracellular and intracellular solutions respectively, and the reversal potential is found to be 0 mV.

What would you conclude about the selectivity of the channel?

What prediction would you make regarding the effect of this channel on the resting membrane potential of the cell if the initial membrane potential is -60 mV and this cation channel is activated? Explain.

Explanation / Answer

This cation channel is open & membrane potential from resting state (-60 mV) has achieved zero mV (voltage has been less negative compared to resting membrane potential.

This illustrates depolarisation phase since sodium channel is open & potassium channel is closed.

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