Name: Homework #4 Complement (10 points) Place the following early events of the

Question

Name: Homework #4 Complement (10 points) Place the following early events of the classical complement pathway in the correct chronological order. (1-earliest event, 8-latest event) (1 point) 1. C3 convertase cleaves C3 into C3a and C3b C4b binds to bacterial cell membrane Numerous C3b bind to bacterial cell membrane C2a binds to C4b to form C4b2a complex C1s cleaves C2 into C2a and C2b Cis cleaves C4 into C4a and C4b Antibody molecules bind to bacterial cell membrane -C1 complex binds to Fc regions of antibody Place the following events of the formation of the membrane attack complex in the correct chronological order. (1-earliest event, 8-latest event) (1 point) 2. _1_ Numerous C3b bind to bacterial cell membrane C5b67 complex binds to C8 -Disruption of bacterial cell membrane C3b binds to C4b2a to form C4b2a3b complex Killing of bacterium C5 convertase cleaves C5 into C5a and C5b C5b binds to C6 and C7 and inserts into bacterial cell wall C9 polymerizes with C5b678 complex to form membrane attack complex Place the following events of complement-induced phagocytosis in the correct chronological order. Assume all of the complement components are cleaved before interaction with the phagocyte. (1 -earliest event, 7-latest event) (1 point) 3. _1_ Numerous C3b bind to bacterial cell membrane C5 convertase cleaves C5 into C5a and CSb Phagocytosis of bacterium -C5a binds to C5a receptors on phagocytes C3b binds to C4b2a to form C4b2a3b complex Phagocytes with CRI receptors bind to C3b Killing of bacterium Place the following events of complement-induced inflammation in the correct chronological order. Assume all of the complement components are cleaved before recruitment of other immune cells. (1 earliest event, 6-latest event) (1 point) 4. 1 Numerous C3b bind to bacterial cell membrane Killing of bacterium C5 convertase cleaves C5 into C5a and C51b C3a and C5a act on blood vessels to increase vascular permeability Migration of immune cells to site of infection C3b binds to C4b2a to form C4b2a3b complex

Explanation / Answer

1. Numerous C3b bind to bacterial cell membrane......> Antibody molecules bind to bacterial cell membrane.....> C1 complex binds to Fc region of the antibody.......> C1s cleaves C4 into C4a and C4b......> C1s cleaves C2 into C2a and C2b........> C2a binds to C4b to form a C4b2a complex....> C4b binds to bacterial cell membrane....> C3 convertase cleaves C3 into C3a and C3b.

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