For the following strand of DNA, use the table below to provide: bases for the c

Question

For the following strand of DNA, use the table below to provide: bases for the complementary mRNA and the associated amino acids. What do you notice about the genetic code for proline in the peptide? How would the loss of the first G or switching that G to a T affect the structure and function of this protein?

DNA:       GGC CTA CAA GCC GGA ACA GTT ACC GCG TAA CGA

RNA: ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???

Amino Acid:??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???
(3 Letters)

Genetic Code Table (mRNA)

2nd  position (middle)

1st position
(5' end)

2nd  position (middle)

3rd position
(3' end) U C A G U Phe F
Phe F
Leu L
Leu L Ser S
Ser S
Ser S
Ser S Tyr Y
Tyr Y
STOP
STOP Cys C
Cys C
STOP
Trp W U
C
A
G C Leu L
Leu L
Leu L
Leu L Pro P
Pro P
Pro P
Pro P His H
His H
Gln Q
Gln Q Arg R
Arg R
Arg R
Arg R U
C
A
G A Ile I
Ile I
Ile I
Met M Thr T
Thr T
Thr T
Thr T Asn N
Asn N
Lys K
Lys K Ser S
Ser S
Arg R
Arg R U
C
A
G G Val V
Val V
Val V
Val V Ala A
Ala A
Ala A
Ala A Asp D
Asp D
Glu E
Glu E Gly G
Gly G
Gly G
Gly G U
C
A
G

Explanation / Answer

DNA: GGC CTA CAA GCC GGA ACA GTT ACC GCG TAA CGA

RNA: CCG GAU GUU CGG CCU UGU CAA UGG CGC AUU GCU

Amino acid: Pro Val Val Arg Pro Cys Gln Trp Arg Ile Ala

The amino acid code for proline is degenerate, meaning any nucleotide in the third position of the codon will result in proline. Therefore switching from G to T will not change the structure or function of the protein. However, if a nucleotide is removed, the entire structure changes as the amino acids following proline will change, changing the sequence and structure of the protein, making it lose it's function.

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