Part E - Change in Conformation Which of the following events most directly lead

Question

Part E - Change in Conformation

Which of the following events most directly leads to the change in pump conformation shown above?

dephosphorylation of the pump

Part F - ATP Binding and K+ Release

Drag each of the terms on the left to correctly complete the sentences on the right. Not all terms will be used.

phosphorylated

releases phosphate

dephosphorylated

Na+

K+

hydrolyzes ATP

1. The Na+?K+ pump binds ________ when the pump is in its dephosphorylated state.

2. The Na+?K+ pump binds ATP when the pump is in its ________ state.

3. The Na+?K+ pump can bind ATP only after the pump_________ .

4. The Na+?K+ pump transports __________ from the extracellular fluid to the cytoplasm.

Part G - Overall Steps in Pump Cycle

Review the steps of primary active transport again by viewing the full Focus Figure 3.1.

Na+ is released into extracellular fluid.

Pump hydrolyzes ATP.

K+ is released into cytoplasm.

Phosphate is released from pump.

Extracellular K+ binds to pump.

Cytoplasmic Na+ binds to pump.

Last step

First step

The correct ranking cannot be determined.

Part H - Phosphorylated and Dephosphorylated States of the Na+?K+ Pump

The Na+?K+ pump switches back and forth between phosphorylated dephosphorylated states as it transports Na+ and K+. Sort the following pump events according to whether they occur while the pump is phosphorylated or dephosphorylated.

K+ binds.

Na+ is released.

ATP binds.

Na+ binds.

K+ is released.

Phosphorylated pump state

Dephosphorylated pump state

the release of K+ into the cytoplasm Na+ binding to the pump K+ binding to the pump

dephosphorylation of the pump

Part F - ATP Binding and K+ Release

Focus your attention on the last step of the Focus Figure.

Drag each of the terms on the left to correctly complete the sentences on the right. Not all terms will be used.

phosphorylated

releases phosphate

dephosphorylated

Na+

K+

hydrolyzes ATP

1. The Na+?K+ pump binds ________ when the pump is in its dephosphorylated state.

2. The Na+?K+ pump binds ATP when the pump is in its ________ state.

3. The Na+?K+ pump can bind ATP only after the pump_________ .

4. The Na+?K+ pump transports __________ from the extracellular fluid to the cytoplasm.

Part G - Overall Steps in Pump Cycle

Review the steps of primary active transport again by viewing the full Focus Figure 3.1.

Assume the pump is in the state shown here. It has just released Na+ into the extracellular fluid. Arrange the subsequent steps of the pump's cycle below in the order they occur AFTER THIS STEP.

Na+ is released into extracellular fluid.

Pump hydrolyzes ATP.

K+ is released into cytoplasm.

Phosphate is released from pump.

Extracellular K+ binds to pump.

Cytoplasmic Na+ binds to pump.

Last step

First step

The correct ranking cannot be determined.

Part H - Phosphorylated and Dephosphorylated States of the Na+?K+ Pump

The Na+?K+ pump switches back and forth between phosphorylated dephosphorylated states as it transports Na+ and K+. Sort the following pump events according to whether they occur while the pump is phosphorylated or dephosphorylated.

K+ binds.

Na+ is released.

ATP binds.

Na+ binds.

K+ is released.

Phosphorylated pump state

Dephosphorylated pump state

Extracellular fluid Extracellular fluid K+ bound Cytoplasm Cytoplasm

Explanation / Answer

E.Dephosphorylation of the pump

F.

1.Hydrolyses ATP

2.Na+

3.dephosphorylation

4.k+.

G.overall steps in pump cycle are as under.

1.pump is open in intracellular fluid.

2.3 Na+ from intracellular fluid binds to the pump.

3.Na+ binding causes ATP to be broken down enzyme ATPase.

4.Energy and phosphate groups bind to the pump.

5.protein changes shape due to addition of protein groups.

6.pump is open to extracellular fluid .

7. 3Na+ are released from the pump and they enter to the extracellular fluid.

8. 2K+ from extracellular fluid binds to the pump.

9.phosphate groups leave pump due to k+ binding .

10.shape of protein is changed .

11.pump open to intracellular fluid.

12.2k+ are released from pump to enter to the intracellular fluid .

13.pump is ready to cycle again .

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