Q18- We want to diagnose a lesion in which hematoporphyrin derivative (HPD) is g

Question

Q18- We want to diagnose a lesion in which hematoporphyrin derivative (HPD) is greatly concentrated. We also want to generate light to photoactivate the compound concentrated into the lesion. An endoscope must be used during the procedure simultaneously. Which steps below would you recommend to achieve this procedure successfully?

a)    Use a CO2laser to diagnose the lesion, a Kr laser to photoactivate HPD and an endoscope made with focused silica fibers.

b)   .Use a red HeNelaser to diagnose to lesion, a Kr laser to photoactivate HPD and an endoscope made with fused silica fibers.

c)     .Use a Kr laser to diagnose the lesion, a red HeNe laser to photoactivate endoscope make with fused silica fibers.

d)    Use a Kr laser to diagnose the lesion, a red HeNe laser to photoactivate HPD and an endoscope made with chalcogenide glass fibers.

e)    .Use an excimer laser to diagnose the lesion and photoactivate HPD. Use an endoscope made with sapphire sibers

Explanation / Answer

answer : C

HEMATOPORPHYRIN DERIVATIVEis a complex mixture of monomeric and aggregated porphyrins with photo sensitizing activity . up on systemic administration,hpd accumulate in tumour cells and, once activated by red laser light (630nm), in the presence of oxygen, produce singlet oxygen and other reactive oxygen radicals, resulting in local radical mediated tumour cell death.

krypton (kr) is dye laser used to diagnose the lesions.

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