Question 1 Which of the following can lie downstream of RTK activation as well a

Question

Question 1

Which of the following can lie downstream of RTK activation as well as GPCR activation? (select any/all answers that apply)

A.

activation of GBPs (GTP-binding proteins)

B.

activation of kinases

C.

Notch activation

D.

Wnt activation

E.

activation of transcription factors

Question 2

Lipid-soluble hormones activate transcription by:

A.

binding to cell surface receptors.

B.

phosphorylating a protein kinase.

C.

binding to a nuclear receptor.

D.

inhibiting a histone deacetylase.

E.

activating the JAK/STAT pathway.

Question 3

In which of the following double-mutant flies will R7 photoreceptors develop normally?

A.

constitutively active Raf and inactive MAPK

B.

constitutively active MAPK and inactive Ras

C.

constitutively active Ras and inactive Raf

D.

all of the above

E.

none of the above

Question 4

By what mechanism does PI-3 phosphate promote activation of PKB (protein kinase B)?

A.

recruiting PKB to the plasma membrane

B.

recruiting PDK1 to the plasma membrane

C.

releasing inhibition of the catalytic site by the PH domain

D.

(a) and (b)

E.

all of (a), (b), and (c)

Question 5

Which of the following signaling pathways can be activated by cytokines?

A.

JAK/STAT

B.

PI-3 kinase

C.

Ras/MAP kinase

D.

(a) and (b)

E.

all of (a), (b), and (c)

A.

activation of GBPs (GTP-binding proteins)

B.

activation of kinases

C.

Notch activation

D.

Wnt activation

E.

activation of transcription factors

Explanation / Answer

true answert is

1)A

2)C

3)A

4)D

5)E

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