QUESTION 7 Which of the following statements regarding the development of cancer

Question

QUESTION 7 Which of the following statements regarding the development of cancer is CORRECT? When a tumor-suppressor gene is mutated, it stops the cell cycle at certain points such as the G1 checkpoint. . Proto-oncogenes can contribute to cancer even when only one allele is mutated; therefore they often show up as dominant (rather than recessive) mutations. Telomerase contributes to the development of cancer when it is no longer able to extend telomeres due to a mutation. When a DNA repair gene is inactivated, the rates of mutation decrease in a cell.

Explanation / Answer

1. Tumour suppressor genes control the cell division by acting through check points. When these genes are mutated, uncontrolled cell division results.

2. Proto oncogenes carry cancer-causing mutations, when they are activated (carry dominant mutations), they will get converted into oncogenes. And start expressing abnormal protein synthesizing genes and uncontrolled cell division.

3. Actually cancer cells increase the expression of telomerase to increase their life span.

4. DNA repair genes are essential for correction of mutated genes. (so rate of mutatoins increases, not decrease)

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