For Exercises 8.4.1 to 8.4.3 perform the ten-step hypothesis testing procedure.

Question

For Exercises 8.4.1 to 8.4.3 perform the ten-step hypothesis testing procedure. Let -.05. 8.4.1. One of the purposes of a study by Liu et al. (A-17) was to determine the effects of MRZ 2/579 on neurological deficit in Sprague-Dawley rats. In this study, 10 rats were measured at four time periods following occlusion of the middle carotid artery and subsequent treatment with the uncompetitive N- methly-D-aspartate antagonist MRZ 2/579, which previous studies had suggested provides neuro- protective activity. The outcome variable was a neurological function variable measured on a scale of 0-12. A higher number indicates a higher degree of neurological impairment. Rat 60 Minutes 24 Hours 48 Hours 72 Hours 10 10 10 Source: Data provided courtesy of Ludmila Belayev, M.D.

Explanation / Answer

NULL HYPOTHESIS H0: [mu1=mu2=mu3=mu4]

ALTERNATIVE HYPOTHESIS HA: AT LEAST TWO MEANS ARE DIFFERENT.

LEVEL OF SIGNIFICANCE = 0.05

n1=10, n2=10, n3=10 and n4= 10

k= 4

SUMMARY :

ANOVA:

CONCLSION: Fcalculated or observed =23.14 which is GREATER than F(3,36)=2.87 critical value at 0.05 level of significance therefore we REJECT THE NULL HYPOTHESIS and may conclude that mean neurological score for four different times are different at 0.05 level of significance.

GROUPS COUNT SUM AVERAGE VARIANCE 60 MINUTES 10 110 11 0 24 HOURS 10 75 7.5 3.83 48 HOURS 10 62 6.2 3.29 72 HOURS 10 52 5.2 3.95

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