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A randomized clinical trial was conducted to test the effectiveness of low-dose

ID: 3355605 • Letter: A

Question

A randomized clinical trial was conducted to test the effectiveness of low-dose aspirin in preventing heart attacks. Patients were randomly assigned to receive either low-dose aspirin or an inactive placebo. There were 11,027 research subjects in the aspirin group, and, after 5 years of observation, there had been a total of 10 fatal heart attacks I this group.

a. What was the proportion of subjects having a fatal heart attack among participants assigned to the low-dose arm of the trial?

b. After computing the decimal fraction, convert your answer into the number of subjects having a fatal heart attack per 10,000 subjects.

Explanation / Answer

(a) Proportion of subjects having fatal heart attack among participants assigned to the low-dose arm of the trial = 10/11027 = 0.0009069

(b) Number of subjects having a fatal heart attack per 10,000 subjects = 0.0009069 X 10,000 = 9.0686

                                                                                                                                    = 9 (rounded to integer)

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