Myasthenia gravis is a serious autoimmune disorder in whichthe body produces ant
ID: 3352 • Letter: M
Question
Myasthenia gravis is a serious autoimmune disorder in whichthe body produces antibodies to its own nicotinic receptors. Whatdo you propose would be the effect of this disease on skeletalmuscle activity? One treatment for this disease involves inhibitorsof cholinesterase (the enzyme that breaks down Ach in the synapse).Why would this help alleviate symptoms of myasthenia gravis?Explain your answers. (2 marks) Please give a full-detailed explaination. Will ratewell. Myasthenia gravis is a serious autoimmune disorder in whichthe body produces antibodies to its own nicotinic receptors. Whatdo you propose would be the effect of this disease on skeletalmuscle activity? One treatment for this disease involves inhibitorsof cholinesterase (the enzyme that breaks down Ach in the synapse).Why would this help alleviate symptoms of myasthenia gravis?Explain your answers. (2 marks) Please give a full-detailed explaination. Will ratewell. Please give a full-detailed explaination. Will ratewell.Explanation / Answer
The effect would be muscle weakness or atonia. In fact that'sbasically what myasthenia gravis means in greek-latin. Thereason there is muscle weakness is because the antibodies bind thenicotinic receptors and the immune system attacks these receptors.When Ach binds nicotinic receptors at the neuromuscular junction itis excitatory (depolarizing) and loss of nicotinic receptorsresults in less excitatory activity, thus less muscle stimulationand muscle weakness. Cholinesterase inhibitors treat thiscondition because they prevent cholinesterase from breaking downAch and allow the neurotransmitter to act and maintain itsexcitatory activity at the synapse for longer. Basically youcan use cholinesterase inhibitors to boosts the activity of theexcitatory neurotransmitter Ach in order to compensate for thedampened excitatory activity due to the loss of nicotinicreceptors.
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