Sickle-cell anemia is a hereditary chronic blood disease that is extremely sever

Question

Sickle-cell anemia is a hereditary chronic blood disease that is extremely severe when an individual carries two copies of the defective gene. It is particularly common in countries plagued by malaria, a parasitic infection transmitted by mosquitoes. A study in Africa tested 543 children for the sickle-cell gene and also for malaria. In Group 1 which consisted of 136 children with the sickle-cell gene, 36 children had severe malaria infections. Group 2 consisted of 407 children without the sickle-cell gene, and 152 of them had severe malaria infections. A 99% confidence interval for the difference in proportions of malaria infections in children with and without the sickle-cell gene is found to be (-0.2243, 0.0068). What is the appropriate conclusion?

There is sufficient evidence that the difference in means of severe malaria infections among children with the sickle-cell trait is significantly different from that in children without.

There is sufficient evidence that the proportion of severe malaria infections is higher among children with the sickle-cell trait.

This question cannot be answered based on a confidence interval.

There is sufficient evidence that the proportion of severe malaria infections is lower among children with the sickle-cell trait.

There is not sufficient evidence that the proportion of severe malaria infections among children with the sickle-cell trait is different from that among children without.

There is sufficient evidence that the difference in means of severe malaria infections among children with the sickle-cell trait is significantly different from that in children without.

There is sufficient evidence that the proportion of severe malaria infections is higher among children with the sickle-cell trait.

This question cannot be answered based on a confidence interval.

There is sufficient evidence that the proportion of severe malaria infections is lower among children with the sickle-cell trait.

There is not sufficient evidence that the proportion of severe malaria infections among children with the sickle-cell trait is different from that among children without.

Explanation / Answer

Since confidence interval contains zero so we cannot concldue that there is a significant difference between the proportions.

There is not sufficient evidence that the proportion of severe malaria infections among children with the sickle-cell trait is different from that among children without.

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