A group of 1,000 female college seniors from a large university were followed\'
ID: 3299498 • Letter: A
Question
A group of 1,000 female college seniors from a large university were followed' for 20 years to investigate the whether the use of oral contraceptives increases women's risk of developing blood clots (thrombo-embolism). Of these females, 592 were oral contraceptive users and 408 did not use oral contraceptives. Among oral contraceptive users, 48 developed blood clots. Among non-users, 22 developed blood clots. None of the females had clots when the study began. 16. Calculate the cumulative incidence of developing blood clots for women in the study. 17. The 1,000 participating women contributed a total of 15,249 person-years of follow up during the study. Using this and the data described in the scenario, calculate the incidence rate for developing blood clots for women in the study (per 10,000 persons per year). 18. Since there are only 15,249 person years of follow-up, it is clear that everyone completed 20 years of follow-up List 2 reasons why some members of the cohort may not have completed 20 years of follow-up.Explanation / Answer
16. Cumulative incidence of developing blood clots = 48+22 = 70
17. Icidence rate = (cumulative incidence / person years of study)x10,000
= (70/15249)x10,000 = 107 per 10,000 person years
18. (It is clear that everyone did not complete 20 years of follow up)
One major reason why the subjects could not complete 20 years of study can be death. 20 years is a very long period and death of some subjects may happen during the study period.
Some subjects may withdraw frm the study and hence they wont share information or they will not follow the study protocol anymore and hence, data frm these people wont be available for the study. This is another reason why members of cohurt may not have completed 20 years of follow-up
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