You will have to construct the appropriate 2x2 tables You have conducted a case-

Question

You will have to construct the appropriate 2x2 tables

You have conducted a case-control study to examine the relationship between eating butter and cardiovascular disease (CVD). You find that among 185 people with CVD, 65 eat butter, while 50 of the 230 control eat butter.

You also find that among the 100 women who have CVD, 25 eat butter. Among the 50 female controls, 5 eat butter. Among the 85 male CVD case, 40 eat butter and among the 180 male controls, 45 eat butter.

Answer these questions:

What is the crude OR?

What are the stratum specific ORs?

What is the overall OR adjusted for the confounding factor?

What is your conclusion? Justify if there is evidence of confounding

Explanation / Answer

for the given 2x2 table

odd ratio  OR=(AD)/(BC)

What is the crude OR?

crude OR=(65*180/(50*125)=1.872

What are the stratum specific ORs?

female specific OR=(25*45)/(5*75)=3

male specific OR=(40*135)/(45*45)=2.67

since male and female specific OR is not equal so there is evidence of confounding and we can say that sex is confounding factor

case control eat butter A B A+B donot eat butter C D C+D total A+C B+D

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