7. In the diagram below, the dscriminator valu s identified by the pointer line

Question

7. In the diagram below, the dscriminator valu s identified by the pointer line which indicates a value of approximately 50 on the x-axis. Discriminator Value Line HEALTHY POPULATION R2SD 2SD DISEASHD POPULATION 10 ? ” 0 5 0 120 TEST VALUES a. The discriminator value set at 50 would result in? (Circle correct answer in each below) i. Increase or decrease in sensitivity i. Increase or decrease in specificity b. Shifting the discriminator line to the right (values greater than 90) would result in? (Circle correct answer in each below) i. Increase or decrease in sensitivity i. Increase or decrease in specificity c. The Reference range for the above healthy population would be about: (Circle the correct answer) i 0 to 90 F6 F7 FB

Explanation / Answer

A)Increase or decrease in sensitivty

B) Increase or decrease in specificity

Assume that the test is for discrimination of only two states, “diseased” (D+) and “non-diseased” (D–), and that the higher test values are more likely among D+persons. Test results equal to or greater than this value are considered positive (T+), otherwise they are negative (T–). The choice of the cut-off value determines the rates of true positive (TP), true negative (TN), false positive (FP), and false negative (FN) test results. The sensitivity of a test is defined as the probability of a positive test (T+) in a diseased person (D+)

Sensitivity = TP/(TP+FN)

The test specificity is defined as the likelihood of a negative test (T–) in a person without the disease (D–)

Specificity = TN/(TN+FP)

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