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Helo I System Announcements and the use of painkillers during pregnancy. Scienti

ID: 3276386 • Letter: H

Question

Helo I System Announcements and the use of painkillers during pregnancy. Scientists interviewed 1009 women soon after they got positive results from around the time of conception or in the early weeks of pregnancy. The researchers then recorded which of the pregnandes were carried to term. The results are in the table below. Miscarriage buprofen Acetaminophen No painkiller Total 13 172 762 1009 145 'U, D-K., et al., " Use of NSAIDs in pregnancy increases risk of miscarriage," British Medical Journal, August 16, 2003; 327(7411): 1.

Explanation / Answer

(a)

Out of 1009 pregnancies, 145 ended up in miscarriage so the required percentage is

145/ 1009 = 0.144 =14.4%

(b)

Asprin group : 5 /22 = 0.227 = 22.7%

Ibuprofen group: 13/53 = 0.245 =24.5%

Acitaminophen : 24/172 = 0.140 =14.0%

No painkiller: 103/762 = 0.135 = 13.5%

(c)

Observational study

(d)

The percentage is

(5+13) / (22+53) = 18 / 75 = 0.24 =24.0%

The use of NSAID appear to increase the miscarriage.

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No becuase percentage is small.

(e)

No

(f)

103/145 = 0.71 =71.0%