1. Steroid hormones are known to increase the expression of specific genes in se
ID: 32731 • Letter: 1
Question
1.Steroid hormones are known to increase the expression of specific genes in selected target cell types. Testosterone increases the production of a protein called alpha-2-microglobulin (?2m) in the liver and hydrocortisone (a glucocorticoid) increases the production of tyrosine aminotransferase (TAT) in the liver. (Each hormone does many other things). All steroid hormone receptors consists of 3 related, but distinct, protein domains: a hormone binding domain, a DNA binding domain, and a regulatory domain.
A.How is it that testosterone and hydrocortisone can selectively influence the expression of two different genes in the same tissue?
B.By what you know of domains, suppose you carry out a domain swap experiment to exchange the DNA binding domains of testosterone receptor and glucocorticoid receptor with each other. What effects would you now expect the two hormones to have in cells containing the altered receptors?
Explanation / Answer
1.the two harmones receptors have different DNA binding specificities and thus regulate different sets of genes
2.the testosterone responsive genes would come under glucocortiroids and glucocortiroids responsive genes would be controlled by testosterones.because harmone binding causes a conformation change that releases the receptor from cytoplasm,ic chaperone , the net effect is that testosteron will now release a protein that regulates glucocoteroids responsive genes and vice versa
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