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Question

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What is the likely effect of greatly increasing the activity of cAMP phosphodiesterase (cAMP PDE) throughout the cell? G alpha cannot be activated. Signaling via the G beta/gamma is blocked. PKG cannot be activated. The catalytic subunits of PKA cannot dissociates from the regulatory subunit. cAMP mediated sigaling is not affected. Which of the following events is an example of negative feedback in a signaling pathway? Binding of the beta/gamma subunits to an alpha subunit of a heterotrimeric GTPase. Binding of ORAI to STM1. Binding of a GEF to a monomeric GTPase. Binding of a GDP-bound heterotrimeric GTPase to adenylyl cyclase. Calcium-calmodulin mediated activation of a membrane localized Ca2+ pumps that moves Ca+ out of the cytoplasm.

Explanation / Answer

Answer 2. The most likely effect of increasing activity of cAMP phosphodiesterase throughout cell is that signally via G beta/gamma can be blocked as well as activated depending on type of cAMP. Adenylyl cyclase type I, III, V, VI and VII can inhibits the signalling effect by decreasing cAMP PDE

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