b. For this experiment clearly name the i) Subjects studied ii) Factor iii) Leve
ID: 3238733 • Letter: B
Question
b. For this experiment clearly name the
i) Subjects studied ii) Factor iii) Levels of the factor iv) Response variables and their units v) Design of the experiment
c. Although blocks were not used in this experiement, suggest a possible blocking variable that could be used to subdivide the type 2 diabetic subjects, and briefly explain what the advantage night be in running the experiment as a randomized block design.
ens, 2007 Jan 25(1):227-34 he effect of vitamin E on blood pressure in individuals with type 2 diabetes Ward NC Wu JH, Clarke MW, Puddey IB, Burke V, Croft KD, Hodgson JM hool of Medicine and Pharmacology, University of Western Australia, Perth, Australia Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, Perth, Australia OBJECTIVE: Oxidative stress has been suggested to play a role in the development of diabetes, hypertension and vascular dystunction. Vitamin b, a major lipid-soluble dietary antioxidant, has two major dietary forms, alpha-tocopherol and gamma-tocopherol. The potential importance of gamma-tocopherol has largely been overlooked. Our aim was to investigate the effect of alpha-tocopherol and gamma-tocopherol upplementation on 24-h ambulatory blood pressure (BP) and heart rate, vascular function and oxidative stress in individuals with type 2 diabetes METHOD: Fifty-eight individuals with type 2 diabetes were randomized in a double-blind, placebo- controlled trial. Participants were randomized to a daily dose of 500 mg/day RRR-alpha-tocopherol, 500 g/day mixed tocopherols or placebo for 6 weeks RESULTS: Treatment with alpha-tocopherol significantly increased systolic BP 17.0 (3.2, 5.8 mmHg, P S 0.0001], diastolic BP 15.3 (4.0, 6.5) mm PExplanation / Answer
Answer:
a. Briefly explain why this is an experiment, not an observational study?
This is an experiment because there is an intervention of subjects by three treatment conditions.
b. For this experiment clearly name the
i) Subjects studied : 48 individuals with type 2 diabetes.
ii) Factor : Treatment (drug types)
iii) Levels of the factor : 3 levels (500mg/day RRR alpha tocopherol, 500mg/day mixed tocopherols, Placebo)
iv) Response variables and their units
BP in mmHg
Heart Rate in bpm
Vascular function
Oxidative stress
v) Design of the experiment
Randomized controlled trial (or randomized control trial; RCT)
c. Although blocks were not used in this experiment, suggest a possible blocking variable that could be used to subdivide the type 2 diabetic subjects, and briefly explain what the advantage might be in running the experiment as a randomized block design.
One possible blocking variable is gender. If we use gender as blocking variable we might eliminate gender difference and find the difference in three treatment conditions.
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