1. Several membrane molecules, in addition to the T-cell receptor, are involved
ID: 323191 • Letter: 1
Question
1. Several membrane molecules, in addition to the T-cell receptor, are involved in antigen recognition. Describe the properties and distinct functions of the following T-cell membrane molecules: a) CD3; b)CD3 and CD4, and c)Zeta chain.
2. Indicate whether each of the properties listed below applies to the T-cell receptor (TCR), B-cell immunoglobulin (Ig), or both (TCR/Ig).
a. _______ Is associated with CD3
b. _______ Is monovalent
c. _______ Exists in membrane-bound and secreted form
d. _______ Contains domains with immunoglobulin-fold structure
e. _______ Is MHC restricted
f. _______ Exhibits diversity generated by imprecise joining of gene segments
g. _______ Exhibits diversity generated by somatic mutation.
Explanation / Answer
1.
a) CD3 : (cluster of differeniation)
it activate Tc cells (cytotoxic)
b) CD3 and CD4:
It activate Th cells
zieta chain it is TCR
2.
a. TCR
b.B-cell
c.B-cell
d. Immunoglobulin
e.TCR
f.both (TCR/Ig)
g.TCR
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