A very rare but serious disease occurs when there is a mutation in the enzyme co

Question

A very rare but serious disease occurs when there is a mutation in the enzyme complex that converts F-6P to F-2,6-BP and vice versa. The mutation results in PFK's impaired ability to produce F-1,6-BP.

1. The mutation is likely in the _____________ portion of the complex. (choices are kinase or phosphatase).

2. This mutation directly negatively affects which pathway (choicesglycolysis, gluconeogenesis, Cori cycle) ____________.

3. Would the pathway be completely inhibited yes or no? _____________.

4. Glycogen storage likely increases or decreases? ______________.

Explanation / Answer

1) answer is kinases( phosphofructokinase mediates an irreversible reaction) 2) all the three pathways, 3) yes fructose 6-phosphate is converted to F-2,6P or vice versa is an irreversible reaction and regulatory step in glycolysis, 4) glycogen is storage form glucose. when glucose levels are higher in the body (due to lack of glycolysis). in such conditions liver converts the excess glucose into glycogen which causes increase in glycogen levels

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