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Investigators are interested in a small exploratory study looking a continuous m

ID: 3180476 • Letter: I

Question

Investigators are interested in a small exploratory study looking a continuous measure taken on three different formulations. Because they expect variability between batches they ran a blocked design where they blocked on the batch. The data are given below. https://home.ubalt.edu/ntsbarsh/Business-stat/otherapplets/ANOVATwo.htm Test for difference between mean responses for the three treatments ignoring batch in the model. What can you conclude? Justify your answer. Re-test the above adjusted for the batch. What do you conclude about mean responses? How does this differ from the prior analyses? Data in the table is a study of blood pressure for different doses (DOSAGE) and different of times used (TIMES). How many different doses were included in the study? Based just on the table what can you conclude about dosage and times applied?

Explanation / Answer

Answer:

1).

One factor ANOVA

Mean

n

Std. Dev

69.3

4

2.22

A

69.8

4

4.11

B

59.5

4

7.59

C

66.2

12

6.78

Total

ANOVA table

Source

SS

   df

MS

F

   p-value

Treatment

267.17

2

133.583

5.04

.0340

Error

238.50

9

26.500

Total

505.67

11

Calculated F=5.04, P=0.034 which is < 0.05 level of significance.

There is significant mean difference between three treatments.

2).

Randomized blocks ANOVA

Mean

n

Std. Dev

69.250

4

2.217

A

69.750

4

4.113

B

59.500

4

7.594

C

63.333

3

9.074

Batch1

64.333

3

4.041

Batch2

64.667

3

8.386

Batch3

72.333

3

2.517

Batch4

66.167

12

6.780

Total

ANOVA table

Source

SS

   df

MS

F

   p-value

Treatments

267.17

2

133.583

9.60

.0135

Blocks

155.00

3

51.667

3.71

.0805

Error

83.50

6

13.917

Total

505.67

11

Calculated F=9.60, P=0.0135 which is < 0.05 level of significance.

There is significant mean difference between three treatments.

In this analysis, we are controlling variation between blocks.

3a)

Three

3b).

The interaction between Dosage and Time is significant, but main effects of Dosage and Time are not significant.

One factor ANOVA

Mean

n

Std. Dev

69.3

4

2.22

A

69.8

4

4.11

B

59.5

4

7.59

C

66.2

12

6.78

Total

ANOVA table

Source

SS

   df

MS

F

   p-value

Treatment

267.17

2

133.583

5.04

.0340

Error

238.50

9

26.500

Total

505.67

11

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