How can I draw out these mutations? Using the following DNA segment and the tran

Question

How can I draw out these mutations? Using the following DNA segment and the translation (note: termeans stop), DRAW an example of each of the following. 5' AUG TTC GGG CCT AAC TGC CCG GGA AGG UGA 3'      met  phe  gly    pro   asn  cys   pro    gly   arg     ter A missense mutation A frameshift mutation A nonsense mutation How can I draw out these mutations? Using the following DNA segment and the translation (note: termeans stop), DRAW an example of each of the following. 5' AUG TTC GGG CCT AAC TGC CCG GGA AGG UGA 3'      met  phe  gly    pro   asn  cys   pro    gly   arg     ter A missense mutation A frameshift mutation A nonsense mutation

Explanation / Answer

A missense mutation is a nucleotide change that causes the codon toencode a different amino acid. So an example of this would bea mutation in the second codon, from TTC to TTA . The encodedamino acid would be 'leu' instead of 'phe'. A frameshift mutation would be the deletion or addition of a singlenucleotide. This will totally change the translation product.An example would be a deletion of the 'C' in the second codon ofthe original sequence. Basically TTC becomes just TT A nonsense mutation is basically a mutation that leads to theencoding of a premature stop codon. The stop codon is justUGA. If we mutate the codon that encodes gly, GGA, to UGAthen you would get a premature stop codon in the codingsequence. I hope I answered your question. Let me know if you need anyclarification.

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