Question III. B1-cell activation by microbial antigens in the absence of T-helpe

Question

Question III. B1-cell activation by microbial antigens in the absence of T-helper cells typically requires that the antigens have repeating determinants that simultaneously cross-link multiple cell-surface B-cell receptors (BCRs). Assess the following statements (47-51) describing the key characteristics of this Tcell-independent pathway of B-cell activation as either factually correct (= “true”) or incorrect (= “false”):

47. Memory B1 cells are generated as a result of the intracellular signaling events triggered by recognition of multi-valent antigens.
48. B-cell apoptosis is induced as a result of the strong signaling received through the cross-linking of multiple BCRs.

49. Multiple different antibody isotypes are produced as a result of the high strength of the activation signal provided.

50. Only IgM isotypes are produced as a result of the failure to undergo class-switching.

51. The antibacterial T-cell-independent responses of B1 cells are mediated mainly through the activation of complement.

Explanation / Answer

47. Memory B1 cells are generated as a result of the intracellular signaling events triggered by recognition of multi-valent antigens. (True)

48. B-cell apoptosis is induced as a result of the strong signaling received through the cross-linking of multiple BCRs. (True)

49. Multiple different antibody isotypes are produced as a result of the high strength of the activation signal provided. (True)

50. Only IgM isotypes are produced as a result of the failure to undergo class-switching. (True)

51. The antibacterial T-cell-independent responses of B1 cells are mediated mainly through the activation of complement. (True)

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