Moving to another question will save this response. Question 1 of 2 stion 1 5 po

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Moving to another question will save this response. Question 1 of 2 stion 1 5 points Save Human erythrocytes have no mitochondria. The rare inherited metabolic disorder that results from pyruvate kinase deficiency is particularly destructive to erythrocytes and causes hemolytic anemia. a) Suggest a reason for increase b) Suggest a reason for the low incidence of mutations in human glycolytic enzymes. d erythrocyte death in the presence of pyruvate kinase deficiency. gi% TTI ? Paragraph Arial : 3(12pt) :?·?·T·?·e HTHL ESS Path: p

Explanation / Answer

Answer . Pyruvate kinase deficiency lead to hemolytic anemia. Pyruvate kinase enzyme is used in the glycolysis pathways which result in ATP production as if there is deficiency in this enzymes lead to less ATP production and the survivability of RBC reduces which lead to early RBC death less RBC count and lead to anemia.

Mutation in human glycolytic enzyme is low because the glycolysis pathway is the main cycle lead to ATP production because in glycolysis result is pyruvate which undergoes into other cycle and ATP production occurs. So it also a housekeeping gene. The probably reason is this that housekeeping gene are less prone to mutation

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