In order for tumor-associated antigens to stimulate the immune response, toleran
ID: 3166212 • Letter: I
Question
In order for tumor-associated antigens to stimulate the immune response, tolerance needs to be broken. How could this be harmful to the individual?
The individual risks developing chronic infections since, in the absence of tolerance, the tumor-associated antigens will stimulate invading pathogens.
The individual risks developing secondary cancers since, in the absence of tolerance, the tumor-associated antigens will suppress anti-cancer lymphocytes.
The individual risks developing autoimmunity since, in the absence of tolerance, the tumor-associated antigens expressed on normal self tissues will be attacked.
All of the above
a.The individual risks developing chronic infections since, in the absence of tolerance, the tumor-associated antigens will stimulate invading pathogens.
b.The individual risks developing secondary cancers since, in the absence of tolerance, the tumor-associated antigens will suppress anti-cancer lymphocytes.
c.The individual risks developing autoimmunity since, in the absence of tolerance, the tumor-associated antigens expressed on normal self tissues will be attacked.
d.All of the above
Explanation / Answer
Ans c) The individual risks developing autoimmunity since, in the absence of tolerance, the tumour-associated antigens expressed on normal self-tissues will be attacked.
In this case, the immune response is stimulated by tumour-associated antigens and hence the tolerance is broken. Since the tolerance is broken, the antigens are not able to differentiate the cells that are foreign and those that are self. This leads to development of auto-immunity in the body
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