The following sequence is the first exon and part of the second of the CFTR gene

Question

The following sequence is the first exon and part of the second of the CFTR gene accessed from the National Center for Biotechnology Information (NCBI) Reference Sequence NM_000492.3. What is the mRNA sequence for this piece of DNA? After you have completed the mRNA sequence, use the chart provided and determine the protein sequence. Remember to start at the start codon and not at the beginning. cgggctctct ggtacgtctc cagcggagac cttttccggt cgcaacagag gtttgaaaaa aagtcgacct ggtctggtta aaactccttt cctatgtctg tcgcggacct taacagtctg tatatggttt agggaagaca actaagacgt ctgttagata gactttttaa cctttctctt accctatctc tcgaccgaag tttcttttta ggatttgagt aattacggga agccgctact aaaaagacct ctaaatacaa gataccttag aaaaatataa

Explanation / Answer

The given DNA Sequence is:

CGGGCTCTCTGGTACGTCTCCAGCGGAGACCTTTTCCGGTCGCAACAGAGGTTTGAAAAAAAGTCGACCTGGTCTGGTTAAAACTCCTTTCCTATGTCTGTCGCGGACCTTAACAGTCTGTATATGGTTTAGGGAAGACAACTAAGACGTCTGTTAGATAGACTTTTTAACCTTTCTCTTACCCTATCTCTCGACCGAAGTTTCTTTTTAGGATTTGAGTAATTACGGGAAGCCGCTACTAAAAAGACCTCTAAATACAAGATACCTTAGAAAAATATAA

The mRNA sequence will be complementary to this sequence , only t will be replaced by U

mRNA sequence

ACC CGA GAG ACC AUG CAG AGG UCG CCU CUG GAA AAG GCC AGC GUU GUC UCC AAA CUU UUU UUC AGC UCC AGA CCA AUU UUG AGG AAA GGA UAC AGC GCC UGG AAU UGU CAC AUA UAC CAA AUC CCU UCU GUU GAU UCU GCA GAC AAU CUA UCU GAA AAU UGG AAA GAG AAU GGG AUA GAG AGC UGG CUU CAA AGA AAA AUC CUA AAC UCA UUA AUG CCC UUC GGC GAU GAU UUU UCU GGA GAU UUA UGU UCU AUG GAA UCU UUU UUA UAUU

Protein sequence will be as follows:

Met-Gln-Arg- Ser- Pro- Leu- Glu-n Lys- Ala- Ser-Val- Val- Ser-Lys- Leu- Phe-Phe-Ser- Ser-Arg- Pro- Iso- Leu- Arg- Lys- Gly- Tyr- Ser- Ala- Trp- Asn- Cys- His- Ile- Tyr- Gln- Ile- Pro- Asp- Ser- Ala- Asp- An- leu- Ser- Glu- Asn- Trp- Lys-Glu- Ser- Trp- Leu- Gln- Arg- Lys- Ile- Leu- Asn- Ser- Leu- Met- Pro- Phe- Gly- Asp- Asp- Phe- Ser- Gly- Asp- Leu- Cys- Ser- Met- Glu- Ser- Phe- Leu- Tyr

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