What is the drawback of immune blockade of CTLA-4 as an anti-tumor therapy? It c
ID: 3165293 • Letter: W
Question
What is the drawback of immune blockade of CTLA-4 as an anti-tumor therapy?
It can lead to autoimmune disease because CTLA-4 normally inhibits autoreactive T cell activation.
It can lead to chronic infection because CTLA-4 normally inhibits memory T cell function.
It can lead to cancer because CTLA-4 normally stimulates anti-cancer T cells.
None of the above.
a.It can lead to autoimmune disease because CTLA-4 normally inhibits autoreactive T cell activation.
b.It can lead to chronic infection because CTLA-4 normally inhibits memory T cell function.
c.It can lead to cancer because CTLA-4 normally stimulates anti-cancer T cells.
d.None of the above.
Explanation / Answer
a. It can lead to autoimmune disease because CTLA-4 normally inhibits autoreactive T cell activation.
Reason: CTLA-4 stops potentially autoreactive T-cells at the initial stage of naive T-cell activation.
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