Which of the following statement about Sickle cell anemia is not correct a. Gene

Question

Which of the following statement about Sickle cell anemia is not correct

a. Genes coding FADs activity increase production of IL-6 and TNF-alpha, which worsen the disease

b. Study have shown there is inverse correlation between level of pro-inflammatory biomarker and Omega-3

c. Mutation at gene coding region of desaturases and inflammatory cytokines responsible for variation and severity of the disease d. Platelet selectin, its ligand, beta-integrin and platelet endothelial cell adhesion molecule-1 are all overexpressed in Sickle cell anemia.

e. All of the above are correct.

Explanation / Answer

a. Genes coding FADs activity increase production of IL-6 and TNF-alpha, which worsen the disease ----> FALSE (the FADs activity decreases in sickle patients, which leads to increased production of IL-6 and TNF-alpha,)

b. Study have shown there is inverse correlation between level of pro-inflammatory biomarker and Omega-3 ---> TRUE (as per the research reports, there is inverse correlation between level of pro-inflammatory biomarker and DHA and EPA (omega-1 fats))

c. Mutation at gene coding region of desaturases and inflammatory cytokines responsible for variation and severity of the disease ----> TRUE

d. Platelet selectin, its ligand, beta-integrin and platelet endothelial cell adhesion molecule-1 are all overexpressed in Sickle cell anemia. ---> TRUE

e. All of the above are correct.

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