17. The best explanation as to why E7V mutation is pathogenic is: A) It is a sub

Question

17. The best explanation as to why E7V mutation is pathogenic is: A) It is a substitution of a negatively charged and non-polar amino acid with a polar one.1 B) It is a substitution of a negatively charged and polar amino acid with a non-polar one. The C) It is a substitution of a positively charged, polar amino acid with a non-polar one. The D) It is a substitution of a non-polar amino acid with a polar one. The presence of a polar E) It is a substitution of a non-polar amino acid with a bulky, polar amino presence of a polar amino acid on the protein surface causes hemoglobin in the deoxygenated state to aggregate and distort the shape of red blood cells. presence of a non-polar amino acid on the protein surface causes hemoglobin in the deoxygenated state to aggregate and distort the shape of red blood cells. presence of a non-polar amino acid on the protein surface causes hemoglobin in the deoxygenated state to aggregate and distort the shape of red blood cells. amino acid on the protein surface causes hemoglobin in the deoxygenated state to aggregate and distort the shape of red blood cells. acid. The presence ulky, polar amino acid on the protein surface causes hemoglobin in the deoxygenated state to aggregate and distort the shape of red blood cells 18. In the genetic code, triplets of nucleotides (codons) specify the amino acids to be added A) 3 C) 16 during protein synthesis. What is the total number of codons in nature? D) 32 19. The central dogma of molecular biology states that genetic information flows from DNA RNA- proteins. Different RNAs play different roles in protein synthesis. Which of the following pairings of RNA and its function is incorrect? A) tRNA/carries amino acids to the ribosome BY rRNA/is important for the structure and function of the ribosome ) mRNA/is copied to make proteins D) tRNA/is an adaptor molecule that decodes the mRNA E) mRNA/is adaptor molecule that carries amino acids to the ribosome, 20. Proteins that are destined to be secreted from eukaryotic cells are synthesized on A) The outer mitochondrial membrane B) The rough ER C) The smooth ER D) The Golgi apparatus E) Peroxisomes

Explanation / Answer

17. The answer is B.

E7V is a mutation of the amino acid residue glutamate (E) to valin (V) at posiiton number 7. E is polar and negatively charged while V is nonpolar amino acid.

18. D. There are a total of 64 codons in nature. as there are 4 nucleotides and each codon as 3, therefore the possible number of combinations are 4^3=64

19. The answer is D. It is the tRNA and not the mRNA which carries the amino acids to the ribisomes during the synthesis.

20. The answer in B. The rough ER contains ribosomes on its surface and is thus called rough. The proteins synthesized on the ribosomes are continuosly passed onto the ER for secretion.

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