Exercice 3 3a) From January to June 2014 (180 days), 27 cases of upper GI bleedi
ID: 3111835 • Letter: E
Question
Exercice 3
3a) From January to June 2014 (180 days), 27 cases of upper GI bleeding (UGIB) have been diagnosed among 9 800 patients treated with Drug A for an average of 17.2 days. What is the incidence rate of UGIB in this population?
3b) Using the drug claims databases, it was possible to determine for each treated patient, the precise treatment duration, as follows:
1 000 patients treated for 2 days
5 000 patients treated for 7 days
2 000 patients treated for 15 days
1 000 patients treated for 30 days
500 patients treated for 60 days
200 patients treated for 120 days
100 patients treated for 180 days
This adverse event can only occur after a patient has been treated for at least 2 months (i.e., risk period starts at 2 months). What is the incidence rate of this event?
3c) Additionally among treated patients, 27 cases of hepatitis were found. According to the pathophysiological pathway, hepatitis can only occur after at least 30 days of treatment, and the risk remains for 15 days after treatment discontinuation. What is the incidence rate of hepatitis in this population?
Exercice 4 : Antipsychotics and cardiovascular events
Two studies, which have respectively been conducted in Canada and the US, found the same relative risk for the association between antipsychotics and cardiovascular events. Assuming that the characteristics of the two treated populations are similar, what information would you need to determine whether the public health impact of antipsychotics in both countries is also the same?
Explanation / Answer
(3a)- 9 800/(180*17.2)=3.16
(3b)-(1000*2)+(5000*7)+(2000*15)+(1000*30)+(500*60)+(200*120)+18000/9900 =1690/99=17.07
(3c)-9800/(180*15)=3.63
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