On the basis of simply counting carbons, a student proposes that two OAA (oxaloa

Question

On the basis of simply counting carbons, a student proposes that two OAA (oxaloacetate) molecules and one palmitate molecule, following the normal metabolic pathways, can be made into four molecules of glucose via gluconeogenesis. Identify and explain the flaw in this conclusion. On the basis of simply counting carbons, a student proposes that two OAA (oxaloacetate) molecules and one palmitate molecule, following the normal metabolic pathways, can be made into four molecules of glucose via gluconeogenesis. Identify and explain the flaw in this conclusion.

Explanation / Answer

The student's logic is wrong because palmitate cannot participate in gluconeogenesis. The reason for it is that palmitate has even no. Of carbons (16) and the even numbered fatty acids give acetyl-CoA when they are oxidized. Acetyl Co-A cannot be used as a substrate for gluconeogenesis. Hence the student's logic is wrong.

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