4. Matthijis et al. (1998) multisystem disorder characterized by defective glyco

Question

4. Matthijis et al. (1998) multisystem disorder characterized by defective glycosylation of glycoconjugates). Are genotypes at this locus at Hardy-Weinberg expected frequencies? Show your calculations, state the degrees of freedom, the statistical null hypothesis of the test, and by referring to the Chi-square table in the textbook (Table 2.5 in textbook or https://www.medcalc.org/manual/chi-square-table.php), explicitly state what you conclude. surveyed a group of 108 people suffering from Jacken syndrome (a genetic Genotype Count OR 86 Sum N 108

Explanation / Answer

Question 4

Null Hypothesis : Given Genotypes follow Hardy - weinberg expected frequencies

Alternative Hypothesis : Given Genotypes doesn't follow Hardy - weinberg expected frequencies.

Here

The expected frequencies are

From this, allele frequencies can be calculated:

p = [2 * OBS (OO) + OBS(OR)]/ [2 * Total frequency]

p = [2 * 22 + 86]/ (2 * 108) = 0.60185

q = 1 - 0.60185 = 0.39815

so here expected frequency are

for OO = 108 * 0.601852 = 39.12

for OR = 2 * 108 * 0.60185 * (1 - 0.60185) = 51.76

for RR = 108 * 0.398152 = 17.12

Here,

X2 = 47.2625

so here degree of freedom dF = 3 - 1 = 2

Here critical value = 5.99

x2 > x2critical

so we reject the null hypothesis and conclude that genotypes suffering fromJaeken syndrome doesn't follows multisystem disorder.

Genotype Observed Expected Chi-square OO 22 39.12 7.492188 OR 86 51.76 22.65026 RR 0 17.12 17.12 sum 47.26245

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