5. Suppose we plan a comparative study of two eye drops (A & B) to reduce the in

Question

5. Suppose we plan a comparative study of two eye drops (A & B) to reduce the intraocular pressure (10P) among patients with glaucoma. A contralateral design is used, in which drop A is assigned to a random eye and drop B is assigned to the other eye. The patients take the eye drops for 1 month, after which their IOP is measured again. The outcome is a decrease in IOP of 5+ mm Hg in an eye. We expect the following: (i) (ii) (iii) (iv) That both eyes will be failures (ie not show a decrease in 5+ mm Hg) in 50% of patients: That both eyes will be successes (ie, will show a decrease of 5+ mm Hg) in 30% of patients; That in 15% of patients the drop A eye will result in a decrease of IOP of 5 + mm Hg but the drop B eye will not That in 5% of patients the drop B eye will show a decrease in IOP of 5 mm Hg but the drop A eye will not. a) What method of analysis can be used to compare the efficacy of drop A to drop B? Explain. (2 pts.) ch How many patients do we need to randomize to achiev e80% power if we have a two- sided test with b) .05 ? 24

Explanation / Answer

A) The method of analysis used is Paired sample T-Test

* Pairedsample test as the result is monitored before and after the use of the drug.

* Since two drugs are used, A and B and we are tocompare the efficacy of both.

Assumptions Assumptions AssumptionsAssumptions Assumptionsforfor paired paired sample T-testtest test:
To run the thepaired paired sample sample t-testtest testdata datadata
$ It should have a normal distribution
$ Check whether it is a large dataset

$ No outlier should be present

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