To possibly improve on the diagnostic accuracy of the clinical diagnosis for Alz

Question

To possibly improve on the diagnostic accuracy of the clinical diagnosis for Alzheimer's disease, information on both the APOE genotype as well as the clinical diagnosis were considered. The data are presented in Table 3.15. Suppose we consider the combination of both a clinical diagnosis for Alzheimer's disease and the presence of 1 e4 allele as a screening test for Alzheimer's disease a. What is the sensitivity of this test? b. What is the specificity of this test? c. What is the ppy? d. What is the npy?

Explanation / Answer

Predicted Yes No Actual -Yes TP = 1643 FN = 190 Actual -No FP = 127 TN = 228 Measure Value Derivations Sensitivity 0.8963 TPR = TP / (TP + FN) Specificity 0.6423 SPC = TN / (FP + TN) Precision 0.9282 PPV = TP / (TP + FP) Negative Predictive Value 0.5455 NPV = TN / (TN + FN)

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