A randomized trial is conducted to test a new drug (Happier) for treatment of de

Question

A randomized trial is conducted to test a new drug (Happier) for treatment of depression. The 1,200 subjects with depression were randomized into equal groups with one group receiving the new drug Happier and the other the conventional treatment (Paxil). After four weeks, researchers assess the effects of the drugs in both groups using questionnaires. Among the Happier group, 400 subjects “improved” compared to 300 subjects in the Paxil group. (1 points)

What is the cumulative incidence of “improvement” in the Happier group? (0.3 points)

What is the cumulative incidence of “improvement” in the Paxil group? (0.3 points)

What is the effect of Happier compared to Paxil in terms of ratio of “improvement”? Interpret the result. (0.4 points)

Explanation / Answer

Solution

(a) cumulative incidence of “improvement” in the Happier group

overall = 400/1200 = 1/3

(b) cumulative incidence of “improvement” in the Paxil group = 300/1200 = 1/4

(c) cumulative incidence of “improvement” in the happier is more than the paxil group i.e. 33% compared to 25%

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