For Q 15, 16: There is a high suspicion that a recently approved drug (XY) for a

Question

For Q 15, 16: There is a high suspicion that a recently approved drug (XY) for arthritis is causing heart attacks (MI). A post-marketing study enrolls 500 patients exposed to Drug XY and 500 controls and followed them up for 1 year, to record the incidence of MIs in both groups. During this year, 35 exposed patients and 15 controls were lost to follow-up. Among the remaining study population, 290 exposed patients and 125 controls developed Ml Q15. What is the relative risk of MI comparing exposed to non-exposed to drug XY? a. 6.85 b. 0.73 C. 2.32 d. 2.61

Explanation / Answer

Solution: Option ( c )

number of patients exposed to Drug XY = 500

number of patients controlled = 500

number of exposed patients developed MI = 290

number of non - exposed patients developed MI = 125

risk of MI among exposed patients = 290/500=0.58

risk of MI among non-exposed patients = 125/500 = 0.25

relative risk of MI comparing exposed to non-exposed to drug XY = 0.58/0.25 = 0.35

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